Diva tells the story of Sam (Regine Velasquez) and her group of friends who want to make it big sa music industry. Martin (TJ Trinidad) is a gifted musician who composes great music, na siya namang nako-compliment ng lyricist na si Gary (Mark Anthony Fernandez) who writes well. Rounding out their merry group is Barbra (Jaya), ang best friend ni Sam who compensates for her lack of musicality by becoming the group's booker/manager.

Fresh from college, the four have banded together in their quest to become big names in the music industry. At agad rin naman silang napansin dahil sa ganda ng boses ni Sam. But there's a problem--the executives who signed them don't think Papin has the right look para sumikat. Enter Lady (Rufa Mae Quinto) and Tiffany (Glaiza de Castro).

Si Lady ang magiging mukha ng kanilang group, with Martin, to become a popular acoustic duo. Ang kaso, ganda lang ang meron si Lady. Sam still continues to sing for the duo, albeit only as a ghost singer for Lady. Si Tiffany naman ang pinsan at alalay ni Lady na fiercely loyal dito, kahit na lagi siyang inaapi nito.

There will come a point na hindi na matitiis ni Sam si Lady. She goes through a makeover and emerges as the new singing sensation: Melody.

Magkikitang muli sina Melody at Tiffany. Nang Makita ang pagpupursige ni Tiffany na sumikat, Melody decides to help her out and turns her into a star. Pero dahil sa pagsikat ni Tiffany, magiging competitor pa siya ni Melody!

Can Melody retain her crown as the Ultimate Diva or mapapalitan ba siya ng sariling protege? Ano ang mangyayari once people find out that Sam and Melody are one and the same? Ano ang magiging reaksyon ni Martin when he finds out that Barbra and Gary knew Melody’s secret all along?

Diva, a comedic drama that revolves around the world of the music industry, premieres very soon on GMA Telebabad.